Immunopathology of Terminal Complement Activation and Complement C5 Blockade Creating a Pro‐survival and Organ‐protective Phenotype in Trauma

Zhangsheng Yang,Miles A. Nunn,Tuan D. Le,Milomir O. Simovic,Peter R. Edsall,Bin Liu,Johnny L. Barr,Brian J. Lund,Crystal D. Hill‐Pryor,Anthony E. Pusateri,Leopoldo C. Cancio,Yansong Li

British Journal of Pharmacology（2022）

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摘要

Previous findings of our and other groups revealed that early TCA represents a rational therapeutic target for trauma patients. Nomacopan as a pro-survival and organ-protective drug, could emerge as a promising adjunct to DCR that may significantly reduce the morbidity and mortality in severe TH patients while awaiting transport to critical care facilities.

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complement,mortality,organ failure,prehospital care,traumatic haemorrhage

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