High-throughput Optofluidic Nanoplasmonic Biosensor Array for Monitoring Single-Cell Secretion in Real-Time

We report a high-throughput biosensing microarray platform integrating ultrasensitive nanoplasmonic substrate and microwell compartments for label-free and real-time secretome monitoring. Interleukin-2 from hundreds of single EL4 cells were measured and a statistical analysis was done.