Real-time OCT Feedback-Controlled RPE Photodisruption in Ex Vivo Porcine Eyes Using 8 Microsecond Laser Pulses

Christian Burri,Simon Salzmann,Jasmin Wandel,Leonie Hoffmann,Boris Povazay,Christoph Meier,Martin Frenz

Biomedical Optics Express（2023）

Bern Univ Appl Sci | Univ Bern

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Abstract

Selective retinal pigment epithelium (RPE) photodisruption requires reliable real-time feedback dosimetry (RFD) to prevent unwanted overexposure. In this study, optical coherence tomography (OCT) based RFD was investigated in ex vivo porcine eyes exposed to laser pulses of 8 µs duration (wavelength: 532 nm, exposure area: 90×90 µm², radiant exposure: 247 to 1975 mJ/µm²). For RFD, fringe washouts in time-resolved OCT M-scans (central wavelength: 870 nm, scan rate: 85 kHz) were compared to an RPE cell viability assay. Statistical analysis revealed a moderate correlation between RPE lesion size and applied treatment energy, suggesting RFD adaptation to inter- and intraindividual RPE pigmentation and ocular transmission.

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Key words

Ocular Radiation Exposure,OCT Imaging,Photoreceptor Degeneration,Retinal Damage,Retinal Detachment

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