Supramolecular Organization and Enzyme-Effector Properties of Double Coordination Salts with Malatostannate/germanate(iv) Anions and Fe(II), Co(II), Ni(II), Cu(II) 1,10-Phenanthroline Cations

Article reports synthesis, structure and characteristics (X-Ray, Elemental, IR-, Hirshfeld surface analysis) of novel supramolecular salts with 1,10-phenanthroline 3d-metals cations and similar malatostannate/ germanate(IV) anions [Fe(phen)(3)](2)[{Sn(HMal)(2)(Mal)}Cl] middot14H(2)O (1), [Co(phen)(3)](2)[{Sn(HMal)2(Mal)}Cl] middot 14H(2)O ( 2 ), [Ni(phen)(3)](2)[{Sn(HMal)(2)(Mal)}Cl] middot14H(2)O ( 3 ), [Cu(phen)(3)](2)[{Sn(HMal)(2)(Mal)}Cl] middot10H(2)O ( 4 ), [Co(phen)(3)](2)[Ge(HMal)(Mal)(2)] middot14H(2)O ( 5 ). It was established that malate anions [Sn(HMal)(2)(Mal)](3-)( 1-4 ) and [Ge(HMal)(Mal)(2)](4 -) ( 5 ) contain same bidentate HMal(2 - )and Mal(3 -) forms and differ only with their number. The Sn/Ge atoms are six-coordinated and their polyhedrons are distorted octahedrons. The specific feature of the compounds 1-4 is the presence of the additional Cl(-)anion, that compensates charge of the two [M(phen)(3) ] (2 + )cations and additionally connects them between each other. Novel supramolecular salts showed themselves as efficient enzyme effectors for alpha-L-rhamnosidase of Cryptococcus albidus because of their structural features (cations as electrophilic hydrophobic and anions as nucleophilic hydrophilic agents) and nature of metal in their composition. Comparing the compounds 1-5 with the previously obtained tartratogermantes/stannates(IV) revealed that difference in the number of hydroxylic groups in the composition of ligands brings a significant change to the structure of the complex anion. (C) 2022 Elsevier B.V. All rights reserved.