Temporal Trend of Sex-Related Differences in the Treatment of ST-Segment Elevation Myocardial Infarction in Young Patients

Studies have found gender-related differences in the management of young adults with ST-segment elevation myocardial infarction (STEMI). 1 Bucholz EM Strait KM Dreyer RP Lindau ST D'Onofrio G Geda M Spatz ES Beltrame JF Lichtman JH Lorenze NP Bueno H Krumholz HM Sex differences in young patients with acute myocardial infarction: a VIRGO study analysis. Eur Heart J Acute Cardiovasc Care. 2017; 6: 610-622 Crossref PubMed Scopus (79) Google Scholar , 2 Pelletier R Humphries KH Shimony A Bacon SL Lavoie KL Rabi D Karp I Tsadok MA Pilote L GENESIS-PRAXY InvestigatorsSex-related differences in access to care among patients with premature acute coronary syndrome. CMAJ. 2014; 186: 497-504 Crossref PubMed Scopus (83) Google Scholar , 3 Arora S Stouffer GA Kucharska-Newton AM Qamar A Vaduganathan M Pandey A Porterfield D Blankstein R Rosamond WD Bhatt DL Caughey MC. Twenty year trends and sex differences in young adults hospitalized with acute myocardial infarction. Circulation. 2019; 139: 1047-1056 Crossref PubMed Scopus (202) Google Scholar , 4 Vallabhajosyula S Ya'Qoub L Singh M Bell MR Gulati R Cheungpasitporn W Sundaragiri PR Miller VM Jaffe AS Gersh BJ Holmes DR Barsness GW. Sex disparities in the management and outcomes of cardiogenic shock complicating acute myocardial infarction in the young. Circ Heart Fail. 2020; 13e007154 Crossref Scopus (27) Google Scholar , 5 Lorente-Ros M Patel A Lorente JA López-de-Sá E. Sex related differences in the treatment of ST-Segment elevation acute myocardial infarction in patients aged <55 years. Am J Cardiol. 2022; 19 (Published online February) Google Scholar However, whether these differences are changing over time is unclear, and the few studies focusing on young patients with STEMI do not include detailed aspects of treatment. 3 Arora S Stouffer GA Kucharska-Newton AM Qamar A Vaduganathan M Pandey A Porterfield D Blankstein R Rosamond WD Bhatt DL Caughey MC. Twenty year trends and sex differences in young adults hospitalized with acute myocardial infarction. Circulation. 2019; 139: 1047-1056 Crossref PubMed Scopus (202) Google Scholar ,6 Udell JA Fonarow GC Maddox TM Cannon CP Frank Peacock W Laskey WK Grau-Sepulveda MV Smith EE Hernandez AF Peterson ED Bhatt DL Get With The Guidelines Steering Committee and Investigators. Sustained sex-based treatment differences in acute coronary syndrome care: insights from the American Heart Association Get With the Guidelines Coronary Artery Disease Registry. Clin Cardiol. 2018; 41: 758-768 Crossref PubMed Scopus (24) Google Scholar , 7 Alkhouli M Alqahtani F Jneid H Al Hajji M Boubas W Lerman A Age-stratified sex-related differences in the incidence, management, and outcomes of acute myocardial infarction. Mayo Clin Proc. 2021; 96: 332-341 Abstract Full Text Full Text PDF PubMed Scopus (14) Google Scholar , 8 Zandecki L Sadowski M Janion M Gierlotka M Gasior M Polonski L. Trends in sex differences in clinical characteristics, treatment strategies, and mortality in patients with ST-elevation myocardial infarction in Poland from 2005 to 2011. Coron Artery Dis. 2017; 28: 417-425 Crossref PubMed Scopus (9) Google Scholar , 9 Khera S Kolte D Gupta T Subramanian KS Khanna N Aronow WS Ahn C Timmermans RJ Cooper HA Fonarow GC Frishman WH Panza JA Bhatt DL. Temporal trends and sex differences in revascularization and outcomes of ST-segment elevation myocardial infarction in younger adults in the United States. J Am Coll Cardiol. 2015; 66: 1961-1972 Crossref PubMed Scopus (138) Google Scholar We aim to determine the temporal trend of gender-related differences in the management of STEMI in patients aged <55 years.