缺血性脑损伤谷氨酸兴奋性毒性发生机制及中药调控作用研究进展

ZHANG Lijuan, ZHANG Qiang,GU Liangzhen,ZHANG Qian,TIAN Xu,MA Ke,ZHAO Haijun,WANG Yuan

Shandong Journal of Traditional Chinese Medicine（2022）

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Abstract
谷氨酸(Glu)兴奋性毒性是缺血性脑损伤发生的关键环节,减少Glu的过度堆积,防止兴奋性毒性产生,对脑缺血的治疗具有重要意义.在缺血性脑损伤中,Glu兴奋性毒性的发生与钙超载、活性氧生成增加、细胞凋亡等病理机制密切相关,并受神经元-星形胶质细胞代谢偶联的调节.通过查阅相关文献,发现对Glu兴奋性毒性具有调控作用的中药包括补虚药、活血药、平肝息风药、开窍药、清热药等,其中以补虚药、活血药为主.参考文献71篇.
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