Poster: CLL-045 The Dedalo Protocol: An Integrated Approach to MRD in CLL Patients Receiving Venetoclax Plus Rituximab

With all patients still on treatment, favorable MRD kinetics was observed in the venetoclax-rituximab setting. The majority of patients achieved PB uMRD after the first cycle of the treatment, with a higher percentage after the sixth cycle. These results are superimposable to those from MURANO trial (at 4 months, uMRD 60%, low MRD positivity 20%, 78% at 6 months). The durability of uMRD rates, their role in the prediction of PFS in a real-life experience, and the effect of genetic characteristics on the MRD kinetics are still under investigation.