AML-131 ERG: from a Fortuitous Discovery to Potential Treatment for AML

Eitan Kugler,Shreyas Madiwale,Darren Yong,Yehudit Birger, Julie Al Thoms,David B. Sykes,Muhammad Yassin,Nasma Aqaqe,Avigail Rein,Hila Fishman,Ifat Geron,Chun-Wei Chen,Brian Raught,Qiao Liu,Michael Milyavsky,John Pimanda,Gilbert G. Prive,Shai Izraeli

Clinical lymphoma myeloma & leukemia/Clinical lymphoma, myeloma and leukemia（2022）

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摘要

Our findings indicate that the aberrant overexpression of ERG maintains HSPCs in an undifferentiated state and promotes AML development. We suggest that the interaction between ERG and the NCoR-HDAC3 complex has an important role in the leukemogenic process, and that HDAC3 inhibition could be beneficial in AML characterized by high ERG expression.

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AML,ERG,Leukemia,HDAC3

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