Microwave-Assisted Approach to Nitroaniline/Aminopyridine and Its Inhibition Activity of Seed Germination

An efficient approach to nitroaniline/aminopyridine was developed under microwave irradiation. The sulphamide and halogenated nitrobenzene/pyridine were used as starting materials. With low consumption, environment friendly, gram-scale synthesis, good substrate scope and excellent product yields, this methodology is superior to the existing approach. Additionally, these compounds 3a-3s could inhibit soybean seed germination at the concentration of 50 mu M. Especially, the inhibition rate of compound 3m was higher than 90%.