Humoral and Cellular Immune Responses to SARS-CoV-2 Vaccination Across Multiple Vaccine Platforms and Liver Disease Types: an EASL Registry Multicentre Prospective Cohort Study

activated memory phenotype and had a marked expansion of plasmablasts by W48.In parallel, ELISPOT data showed an increase in SFU against HBsAg in the 3 patients with HBsAg loss and anti-HBs+ by W48, confirming the recovery of antibody-producing functionality.Conclusion: Functional cure (HBsAg loss) and viral control following NA withdrawal associate with recovery of the low frequencies and poor functionality of HBV-specific B cells in CHB.These findings support larger studies to explore the use of B cells as biomarkers of clinical outcome and as targets for further immunotherapeutic boosting.