In vitro antimicrobial and anti-proliferative activity of crude methanolic extract of pigment from Streptomycetes spp. on HT-1080 fibro sarcoma cell line

The ability to produce secondary metabolites like antibiotics is the characteristic feature of Streptomyces. Besides antibiotics, they are also seen to produce other bioactive compounds of economic importance like pigments which are potentially used in industries with remarkably appealing results. Under this backdrop, extraction of such priceless molecule from microbial source was the aim of this work. Actinomycetes strain isolated from water sample was identified as Streptomycetes with conventional and molecular approach. The metabolite exhibited antibacterial, antioxidant and anticancer activity as evident from the liquid fermentation. The crude ethanolic pigment extract was shown to be antibacterial on gram negative human pathogens. Also it exhibited antioxidant and anticancer activity against two cancer cell lines i.e. HeLa and HT-1080. Pigments from bacteria can be effectively used as natural source of treatment against various human ailments. Our results provide insights into effective role of pigment as potent bioactive metabolites with effective pharmaceutical properties.