Versatile Fully-Substituted Triazole-Functionalized Polypeptides with a Stable Α-Helical Conformation for Gene Delivery

Xiang Xu,Shuxin Liu,He Gao,Ming Li,Junnan He,Yubin Zheng,Wangze Song,Nan Zheng

Polymer chemistry（2022）

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摘要

A library of polypeptides bearing fully-substituted triazoles (FT) was developed via a Cu-catalyzed multicomponent reaction (MCR), which avoided the undesired hydrogen bonding and stabilized the α-helix in a broad pH range.

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