0673 Script-Driven Imagery in PTSD: Comparing Reactivity to Imagery of Trauma Memories to Imagery of Trauma-Nightmare Memories

Augustus Kram Mendelsohn,Scott Orr,Vladimir Ivkovic, Elizabeth Fortier,Anne Kelly,Doga Cetinkaya,Uriel Martinez,Oren Bazer,Kaloyan Tanev,Natasha Lasko,Suzanne Pineles,Edward Pace-Schott

Sleep（2022）SCI 2区

Massachusetts Gen Hosp | Harvard Med Sch | Boston Vet Affairs

Cited 0|Views14

Abstract

Abstract Introduction Prolonged Exposure (PE) therapy produces therapeutic fear extinction via imaginal exposure to trauma memories. However, traumatic events that occurred in the distant past and the associated memories may become distorted or habituated. Posttraumatic nightmares are more recent, potentially salient, and may better support extinction learning. Physiological responses to imagery of a trauma and nightmare related to this trauma were compared to each other and to neutral imagery. Methods Twelve participants (mean age=26.16, 11 female) with PTSD (mean CAPS-5=27.83) and frequent trauma-related nightmares wrote accounts of their trauma. Participants then completed a 14-day sleep-monitoring period with diaries, actigraphy and two nights of ambulatory PSG. Participants narrated a nightmare report into an audio recorder when awoken by a nightmare or when recalled upon awakening. Two pairs of short narratives were created from the written account of the trauma and recording of a nightmare most similar to the trauma. These narratives (scripts) were audio-recorded by an investigator. Participants then underwent two script-driven imagery (SDI) sessions, one hour apart, during which they listened to either their two trauma-memory or their two nightmare-memory scripts (counterbalanced across participants) with 3 interspersed neutral scripts. Each script in an SDI session included baseline, listening, and imagery periods (approximately 30 sec apiece). Skin conductance (SC), heart rate (HR), and corrugator electromyography (EMG) biosignals were continuously recorded throughout each SDI session. For each script, HR, SC, and EMG means during the baseline period were subtracted from their respective imagery-period means. These difference scores were square-root transformed and analyzed by ANOVA with Type (trauma vs. nightmare) and Valence (trauma/nightmare vs. neutral) factors. Results Biosignals from scripts of both Types (trauma and nightmare) significantly exceeded those from their respective neutral scripts [HR:F(1,11)=23.42, p=0.0005; SC:F(1,11)=9.53, p=0.01; EMG:F(1,10)=8.0, p=0.018]. However, biosignals from trauma and nightmare scripts did not differ (p’s>0.39) nor did the Type x Valence interactions (p’s>0.10). Conclusion Physiological reactivity during imagery of a trauma memory and a trauma-related nightmare both significantly exceeded reactivity to neutral scenarios. Nightmare-memory and trauma-memory imagery produced similar reactivity. Thus, imagery of nightmares have potential utility as alternative PE stimuli. Support (If Any) This project was supported by NIMH grant 1R21MH121832-01A1 to E.P.S.

Translated text

求助PDF

上传PDF

Bibtex

AI Read Science

AI Summary

AI Summary is the key point extracted automatically understanding the full text of the paper, including the background, methods, results, conclusions, icons and other key content, so that you can get the outline of the paper at a glance.

Example

Background

Key content

Introduction

Methods

Results

Related work

Fund

Key content

Pretraining has recently greatly promoted the development of natural language processing (NLP)
We show that M6 outperforms the baselines in multimodal downstream tasks, and the large M6 with 10 parameters can reach a better performance
We propose a method called M6 that is able to process information of multiple modalities and perform both single-modal and cross-modal understanding and generation
The model is scaled to large model with 10 billion parameters with sophisticated deployment, and the 10 -parameter M6-large is the largest pretrained model in Chinese
Experimental results show that our proposed M6 outperforms the baseline in a number of downstream tasks concerning both single modality and multiple modalities We will continue the pretraining of extremely large models by increasing data to explore the limit of its performance

Upload PDF to Generate Summary

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Data Disclaimer

The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn

Chat Paper

【要点】：本研究比较了创伤记忆和与创伤相关的噩梦记忆在脚本驱动想象中的生理反应性，发现两者的反应性相似，表明噩梦记忆可能作为 prolonged exposure (PE) 治疗的替代刺激。

【方法】：采用脚本驱动想象（SDI）方法，让12名患有创伤后应激障碍（PTSD）的参与者分别听创伤记忆和创伤相关噩梦的音频脚本，并记录生理信号。

【实验】：参与者完成了14天的睡眠监测，包括日记、活动记录和两次夜间便携式睡眠监测（PSG）。创建了与创伤和最接近创伤的噩梦相对应的两对简短叙述（脚本），并在两个SDI会话中播放这些脚本，每个会话间隔一小时。通过分析皮肤电导（SC）、心率（HR）和皱眉肌电图（EMG）的数据，发现创伤和噩梦脚本的生理反应性均显著高于中性脚本。实验使用的数据集为参与者自己的创伤和噩梦叙述。