Correction and Prevention of Hyponatremia in Patients with Cirrhosis and Ascites-Post Hoc Analysis of the ANSWER Study Database

INTRODUCTION:We assessed the impact of long-term albumin administration to hyponatremic patients with ascites enrolled in the ANSWER trial.METHODS:The normalization rate of baseline hyponatremia and the 18-month incidence rate of at least moderate hyponatremia were evaluated.RESULTS:The hyponatremia normalization rate was higher with albumin than with standard medical treatment (45% vs 28%, P = 0.042 at 1 month). Long-term albumin ensured a lower incidence of at least moderate hyponatremia than standard medical treatment (incidence rate ratio: 0.245 [CI 0.167-0.359], P < 0.001).DISCUSSION:Long-term albumin administration improves hyponatremia and reduces episodes of at least moderate hyponatremia in outpatients with cirrhosis and ascites.