Mucopenetration study of solid lipid nanoparticles containing magneto sensitive iron oxide

Stefano Castellani,Adriana Trapani,Giovanna Elisiana Carpagnano,Antonella Cotoia,Onofrio Laselva,Maria Pia Foschino Barbaro,Filomena Corbo,Gilda Cinnella,Elvira De Giglio, Domenico Larobina,Sante Di Gioia,Massimo Conese

European Journal of Pharmaceutics and Biopharmaceutics（2022）

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摘要

•Sputum and aspirated secretions were obtained from COPD patients.•PEGylated mSLNs penetrated porcine gastric mucus (PGM) > Sputum > Aspirated secretions.•Elastic moduli followed a definite trend: PGM > Aspirated secretions ≥ Sputum.•The magnetic field increased mSLNs interaction with primary airway epithelial cells.

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关键词

Solid lipid nanoparticles,Magnetic field,Rheometry,Mucopenetration,Airway epithelial cells

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