Network pharmacology and molecular docking approaches to elucidate the potential compounds and targets of Saeng-Ji-Hwang-Ko for treatment of type 2 diabetes mellitus

Computers in Biology and Medicine(2022)

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摘要
•Network pharmacology and molecular docking showed potential antidiabetic compounds and targets of Saeng-Ji-Hwang-Ko (SJHK).•Kaempferol and β-sitosterol were primary druggable compounds of SJHK for type 2 diabetes mellitus (T2DM) treatment.•PTGS2, ESR1, PRKAA2, PRKAB1, and CYP19A1 were key targets of SJHK for T2DM treatment.•KEGG pathway analysis revealed five signaling pathways related to T2DM.
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关键词
Saeng-Ji-Hwang-Ko,Type 2 diabetes mellitus,Network pharmacology,Molecular docking,Anti-diabetic mechanism
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