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Loss of Nuclear Envelope Integrity and Increased Oxidant Production Cause DNA Damage in Adult Hearts Deficient in PKP2: A Molecular Substrate of ARVC

Marta Perez-Hernandez,Chantal J. M. van Opbergen,Navratan Bagwan,Christoffer Rasmus Vissing,Grecia M. Marron-Linares,Mingliang Zhang,Estefania Torres Vega,Andrea Sorrentino,Lylia Drici,Karolina Sulek,Ruxu Zhai,Finn B. Hansen,Alex Horby Christensen,Soren Boesgaard,Finn Gustafsson,Kasper Rossing,Eric M. Small,Michael J. Davies,Eli Rothenberg,Priscila Y. Sato,Marina Cerrone,Thomas Hartvig Lindkaer Jensen,Klaus Qvortrup,Henning Bundgaard,Mario Delmar,Alicia Lundby

Circulation（2022）

Cited 12|Views66
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Key words
arrhythmogenic right ventricular dysplasia,DNA damage,nuclear envelope,oxidative stress,plakophilins,sirtuin 3
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