Deficient Chaperone-Mediated Autophagy in Macrophage Aggravates Inflammation of Nonalcoholic Steatohepatitis by Targeting Nup85.

Miao Zhang,Siyuan Tian,Shuoyi Ma,Xia Zhou,Xiaohong Zheng,Bo Li,Guanya Guo, Jhao Yu,Rui Su,Fangfang Yang,Yinan Hu,Gang Ma,Hui Yang,Linhua Zheng,Changcun Guo,Yulong Shang,Jingbo Wang,Ying Han

Liver international : official journal of the International Association for the Study of the Liver（2023）

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摘要

We proposed that the impaired CMA-induced Nup85 degradation aggravated monocyte recruitment, promoting liver inflammation and disease progression of NASH.

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关键词

Chaperone-mediated autophagy,NASH,Nup85,inflammation,macrophage

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