Current Status and Outlook of Porous Zn-based Scaffolds for Bone Applications:A Review

Over the past 5 years,many works have been performed to reveal the potentials of Zinc(Zn)-based materials as temporary bone scaffolds with the expectation that their emergence could address some of the main concerns associated with magne-sium-and iron-based materials.Thanks to the emerging Additive Manufacturing(AM)technology,it facilitates the optimi-zation of the design and production of topological porous Zn-based materials suited for bone scaffolds.Since the studies on the porous Zn-based scaffolds are on the rise,we provide the most current progress in the development of porous Zn-based scaffolds for bone applications.The impacts of recently developed topological design from the AM as well as the advanced dynamic-flow corrosion on their corrosion,mechanical properties,and in vitro biocompatibility are also presented.Plus,we identify a number of research gaps and the challenges encountered in adopting porous Zn-based scaffolds for orthopedic applications and suggest some promising areas for future research.