Circulating Tumor DNA As a Cancer Biomarker: an Overview of Biological Features and Factors That May Impact on Ctdna Analysis.

Estela Sanchez-Herrero,Roberto Serna-Blasco,Lucia Robado de Lope,Victor Gonzalez-Rumayor,Atocha Romero,Mariano Provencio

Frontiers in oncology（2022）SCI 3区

Biomed Sci Res Inst Puerta Hierro Majadahonda | Atrys Hlth

Cited 30|Views22

Abstract

Cancer cells release nucleic acids, freely or associated with other structures such as vesicles into body fluids, including blood. Among these nucleic acids, circulating tumor DNA (ctDNA) has emerged as a minimally invasive biomarker for tumor molecular profiling. However, certain biological characteristics of ctDNA are still unknown. Here, we provide an overview of the current knowledge about ctDNA biological features, including size and structure as well as the mechanisms of ctDNA shedding and clearance, and the physio-pathological factors that determine ctDNA levels. A better understanding of ctDNA biology is essential for the development of new methods that enable the analysis of ctDNA.

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Key words

ctDNA= circulating tumor DNA,ctDNA kinetics,biomarker,liquid biopsy,monitoring

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Pretraining has recently greatly promoted the development of natural language processing (NLP)
We show that M6 outperforms the baselines in multimodal downstream tasks, and the large M6 with 10 parameters can reach a better performance
We propose a method called M6 that is able to process information of multiple modalities and perform both single-modal and cross-modal understanding and generation
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