Discovery and Biological Evaluation of 1-{2,7-diazaspiro[3.5]nonan-2-yl}prop-2-en-1-one Derivatives As Covalent Inhibitors of KRAS G12C with Favorable Metabolic Stability and Anti-Tumor Activity.
Bioorganic & medicinal chemistry（2022）
关键词
KRAS G12C mutation,Non-small cell lung cancer,Acryloyl amine,GSH reactivity,In vivo efficacy
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