Phosphorylated Tau Sites That Are Elevated in Alzheimer's Disease Fluid Biomarkers Are Visualized in Early Neurofibrillary Tangle Maturity Levels in the Post Mortem Brain

Alzheimer's disease (AD) biomarkers are increasingly more reliable in predicting neuropathology. To facilitate interpretation of phosphorylated tau sites as an early fluid biomarker, we sought to characterize which neurofibrillary tangle maturity levels (pretangle, intermediary 1, mature tangle, intermediary 2, and ghost tangle) are recognized.