COVID-associated Rhinocerebral Mucormycosis: a Retrospective Analysis of Presentation and Outcomes.

European archives of oto-rhino-laryngology/European archives of oto-rhino-laryngology and head & neck(2022)

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摘要
OBJECTIVES:To comprehensively analyse the disease presentation and mortality of COVID-associated rhino-orbito-cerebral mucormycosis.METHODS:A retrospective analysis of the demographics, clinical and radiographic findings was performed. A binary logistic regression analysis was performed to examine the survival of patients with mucormycosis from hypothesised predictors.RESULTS:A total of 202 patients were included in this study. Statistical significance was demonstrated in the predilection to the male gender, recent history of SARS-COV-2, history of use of corticosteroid and hyperglycemia in this cohort of CAM. The mortality rate was 18.31%. Advanced age, raised HbA1c and intra-orbital extension were found to be predictors adversely affecting survival.CONCLUSION:Early diagnosis, aggressive surgical therapy, early and appropriate medical therapy can help improve outcomes.LEVEL OF EVIDENCE:Level 4.
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关键词
Mucormycosis,COVID,Rhino-cerebral,Rhino-orbito-cerebral mucormycosis,ROCM,COVID-associated mucormycosis,CAM
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