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Modified aqueous mobile phases: A way to improve retention behavior of active pharmaceutical compounds and their impurities in liquid chromatography

Journal of Chromatography Open(2022)

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摘要
•Mobile phase modification in RP-HPLC as a solution for common analytical challenges.•Chaotropic agents, micelles and cyclodextrin as mobile phase additives.•Micellar and cyclodextrin-modified liquid chromatography as green alternatives.
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关键词
Mobile phase modifications,Chaotropic chromatography,Micellar liquid chromatography,β-CD-modified RP-HPLC,Retention modeling
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