Modulation of Ventromedial Orbitofrontal Cortical Glutamatergic Activity Affects the Explore/Exploit Trade-Off and Influences Reward-Related Decision-Making

Cognitive flexibility and the balance between exploration and exploitation are essential for reward-related decision-making. The orbitofrontal cortex (OFC) is pivotal to these processes. Since impairments in OFC function and glutamatergic abnormalities are evident in several psychiatric disorders, we investigated how ventromedial OFC (vmOFC) glutamate neuron activity modulation affects reward-related decision-making,