Potential Effects of Hesperidin and Naringenin Alone or Combined Against Experimentally Induced Hepatic Steatosis in Obese Rat Model

Natural products with a long history of safety can modulate obesity. Hesperidin and naringenin have garnered attention for their antioxidant and antiobesity activities. The present study was conducted to evaluate the potential role of Hesperidin and Naringenin alone or combined against high fat diet induced steatohepatitis. Sixty male albino rats which were equally subdivided into four groups in which hesperidin, naringenin or hesperidin/naringenin thistle combination were administered for 8 weeks alongside high fat diet. Insulin resistance, glucose tolerance, lipogenesis and antioxidant capacity were evaluated. Best results were for hesperidin/naringenin combination group. Both hesperidin and naringenin alone or combined improved glucose tolerance and insulin sensitivity, decreased lipogenesis and increased antioxidant capacity with best results obtained in hesperidin/naringenin combination group, implying a potential application in the treatment of hepatic steatosis associated obesity.