MOF-253 immobilized Pd and Cu as recyclable and efficient green catalysts for Sonogashira reaction

MOF-253 center dot Pd(OAc)(2) and MOF-253 center dot CuI were prepared, characterized, and evaluated firstly as heterogeneous co-catalysts, which showed high catalytic activity in Sonogashira coupling reaction of various substituted (hetero)aryl halides with terminal alkynes at 70-120 degrees C, and afforded the corresponding products in 45-99% yields with high TON (similar to 2722 for Pd). The best result was achieved with an extremely low Pd (0.036 mol%) and Cu (0.397 mol%) loading. Moreover, the catalysts can be reused at least five times without significantly reducing the activity. Besides, Hg(0) and PVP-poisoning experiments confirmed that the present catalysts were efficient and heterogeneous catalysts in this coupling reaction. (C) 2022 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.