PD-1/PD-L1 Correlates With the Efficacy of the Treatment of Concurrent Chemoradiotherapy in Cervical Cancer
FRONTIERS IN ONCOLOGY(2022)
摘要
BackgroundCervical cancer (CC) is the third most common cancer worldwide, with high mortality rates. The programmed cell death 1 (PD-1)/(PD-1 ligand) PD-L1 has been reported to be an effective indicator in cancer development. In this study, we aim to explore the role of PD-1/PD-L1 in the evaluation of concurrent chemoradiotherapy (CCRT) efficacy and prognosis in CC patients. MethodsWe included 55 CC patients in this study. Immunohistochemistry and flow cytometry were employed to detect the expression of PD-1, T-reg cells, CD8, and CD68 in tumor tissues, and the contents of PD-1(+) CD8(+) T cells, PD-1(+) CD4(+) T cells, and PD-1(+) T-reg cells in the peripheral blood. The relationships of these indexes with CCRT efficacy were measured by Spearman correlation analysis, overall survival (OS), and disease-free survival (DFS) of patients were analyzed by Kaplan-Meier estimator, and the diagnostic values of these indexes in CC were assessed by a receiver operating characteristic (ROC) curve. ResultsThe clinical effectivity rate of CCRT was 89.10%. The positive expressions of PD-L1, T-reg cells, PD-1(+) CD8(+) T cells, PD-1(+) CD4(+) T cells, and PD-1(+) T-reg cells were reduced after CCRT, while the CD8 and CD68 increased. All 7 indexes had diagnostic values in evaluating CCRT efficacy and were considered the influencing factors of OS, DFS, and the prognosis of CC patients. ConclusionThese findings indicate that PD-1/PD-L1 may be a potential indicator for the efficacy evaluation of CCRT and the prognosis of CC. This study may offer potential targets for CC treatment.
更多查看译文
关键词
cervical cancer, programmed cell death 1, programmed cell death 1 ligand, concurrent chemoradiotherapy, prognosis
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要