Clinicopathologic and genomic features of high-grade pattern and their subclasses in lung adenocarcinoma

Bokyung Ahn,Shinkyo Yoon,Deokhoon Kim,Sung-Min Chun,Goeun Lee,Hyeong-Ryul Kim,Se Jin Jang,Hee Sang Hwang

Lung Cancer（2022）

引用 8|浏览15

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摘要

•Clinicopathologic features and survival of IASLC grade 3 LUAD are not uniform.•Stratification of IASLC grade 3 LUAD by high-grade pattern reveals distinct subgroup.•TP53 and RB1 alterations in LUAD predict poor survival outcome.

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关键词

Lung adenocarcinoma,Histologic grading,Next-generation sequencing,TP53 gene,Cell cycle-related genes

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