Role of Homocysteine Metabolism in Cardiovascular Diseases

Homocysteine is a methyl group metabolic intermediate that requires numerous B-vitamin cofactors in the diet to function properly. The relationship between homocysteine metabolism and health and disease is becoming more well-known. Homocysteine metabolism disturbances, primarily intracellular and subsequent circulatory homocysteine buildup (hyperhomocysteinemia), are linked to vascular disease risk and other diseases. On the other hand, B-vitamin treatment has successfully restored average homocysteine concentrations without corresponding decreases in disease risk. As a result, researchers are still investigating the molecular link between homocysteine equilibrium and disease states and the efficacy of homocysteine regulation.