谷歌浏览器插件
订阅小程序
在清言上使用

Chirality Transfer and Asymmetric Catalysis: Two Strategies Toward the Enantioselective Formal Total Synthesis of (+)-Gelsenicine

Organic letters(2022)

引用 2|浏览7
暂无评分
摘要
Two strategies are described en route to an enantioselective total synthesis of gelsenicine. One approach centers on a chirality transfer cycloisomerization that ultimately fell short. Separately, an asymmetric catalysis route utilizing bisphosphine-gold-catalyzed cycloisomerization was pursued. A catalytic system was identified that provided a synthetic intermediate in our Gelsemium alkaloid syntheses in high enantiopurity and with absolute configuration determined by electronic circular dichroism, thus representing an enantioselective formal total synthesis of (+)-gelsenicine.
更多
查看译文
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要