MO132: Gait Speed in Predialysis Chronic Kidney Disease Patients: A Cross-Sectional Study from the Role of AST120 in Sarcopenia Prevention in Pre-Dialysis Chronic Kidney Disease Patients

Abstract BACKGROUND AND AIMS Gait speed (GS) is an important measure of functional ability. The aim of this study was to investigate the factors associated with GS in patients with chronic kidney disease with respect to sarcopenic component, plasma uremic or inflammatory markers and quality of life. METHOD The RolE of AST120 in sarCOpenia preVEntion in pRe-dialYsis chronic kidney disease patients is a 48-week, randomized controlled, parallel group, open-label, multicentre trial to determine the role of AST-120 in patients with chronic kidney disease. A total of 150 study participants were recruited from six general hospitals in South Korea. The participants were classified into four groups according to GS: ≤0.8, 0.8–1.0, ≤1.0–1.3 and ≥1.3 m/s. Linear regression analysis was performed to identify the factors associated with GS. RESULTS The mean GS was 1.06 ± 0.3 m/s. The mean age of the total population was 65.0 ± 10.8 years, and 97 (64.7%) were males. The group with a GS ≤ 0.8 m/s was the oldest and had the highest proportion of participants with low education level and medical aid. The levels of albumin, creatinine, eGFR and proteinuria did not differ between the groups. Participants with a GS ≤ 0.8 m/s showed the lowest level of physical component scale (PCS) and mental component scale (MCS). The levels of IS, TNF-α and myostatin were not different between the groups; however, the level of IL-6 showed a higher trend in the lower GS group. HGS and GS showed weak correlations with one another (R2 = 0.066, P < .001); however, GS and the SMI were not significantly associated (R2 = 0.016, P = .119). In the multivariate linear regression analysis adjusted for age, sex, diabetes, and estimated glomerular filtration rate, medical aid (β = –18.4, P = .007), handgrip strength (β = 0.85, P = .031), interleukin-6 level (β = –13.2, P = .001), haemoglobin (β = 2.84, P = .041), MCS (β = 0.45, P < .001) and PCS (β = 0.51, P < .001) were significantly associated with GS. Specifically, physical functioning, role limitation due to physical health problems and bodily pain in PCS, role limitation due to emotional problems, vitality and social functioning in MCS were statistically significantly correlated with GS. In the kidney disease-specific scale, symptom/problem, work status, cognitive function, quality of social interactions, social support and overall health rating in kidney disease were statistically significantly correlated with GS in the multivariate analysis. CONCLUSION GS is associated with handgrip strength, interleukin-6 and various components of quality of life including MCS and PCS.