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A Hybrid of Amodiaquine and Primaquine Linked by Gold(I) is a Multistage Antimalarial Agent Targeting Heme Detoxification and Thiol Redox Homeostasis

Caroline De Souza Pereira,Helenita Costa Quadros,Samuel Yaw Aboagye,Diana Fontinha,Sarah D'Alessandro, Margaret Elizabeth Byrne,Mathieu Gendrot,Isabelle Fonta,Joel Mosnier,Diogo Rodrigo M. Moreira,Nicoletta Basilico,David. L. L. Williams,Miguel Prudencio,Bruno Pradines,Maribel Navarro

PHARMACEUTICS（2022）

Cited 3|Views52
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Key words
malaria,Plasmodium,antimalarial drugs,quinolines,gold,heme detoxification,redox homeostasis,hemozoin,flavoenzymes
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