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Gut Microbiota: the Servant of Human Being and the Accessary of Tumorigenesis

Trends in oncology(2020)

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摘要
Gut microbiome affects multiple facets of human health and is inextricably linked to tumorigenesis. Substantial research has aimed to understand how gut microbiome functions in the homeostasis of our body. This review explores the evidence demonstrating how the gut microbiome may affect body health, thereby having an impact on metabolism, protection, nutrition and some anatomical-functional relationship. Alterations in gut microbiota composition have been associated with plenty disorders. Of interest, majority of researches demonstrate the role of microbiota in cancer. However, they haven’t been classified systematically. We divided them into tumor in situ, gut-biliary tract cancer axis, gut-breast cancer axis, gut-haematopoiesis cancer axis and gut-brain cancer axis. In addition, we introduce the latest method in diagnosis and treatment of related cancer.
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