Up-regulation of POM121 is linked to prostate cancer aggressiveness and serves as a prognostic biomarker

Finn Becker,Anne Offermann,Marie C. Roesch,Vincent Joerg,Doris Roth,Verena Lubczyk,Rainer Kuefer,Verena Sailer,Jutta Kirfel,Axel S. Merseburger,Sven Perner

Urologic Oncology: Seminars and Original Investigations（2022）

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摘要

•POM121 expression increases during prostate cancer progression.•Expression of POM121 associates with biochemical recurrance.•Intranuclear Androgen receptor expression correlates with POM121 expression.•POM121 serves as a prognostic biomarker and might be a therapeutic target.

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关键词

Prostate cancer,Biomarker,Nuclear pore complex,Nucleoporins,POM121,Androgen receptor

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