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Discovery and Preclinical Profiling of GSK3839919, a Potent HIV-1 Allosteric Integrase Inhibitor

Kyle Parcella,Tao Wang,Kyle Eastman,Zhongxing Zhang,Zhiwei Yin,Manoj Patel,Yong Tu,Barbara Zhizhen Zheng,Michael A Walker,Mark G Saulnier,David Frennesson,Michael Bowsher,Eric Gillis,Kevin Peese,Makonen Belema,Christopher Cianci,Ira B Dicker,Brian McAuliffe,Bo Ding,Paul Falk,Jean Simmermacher,Dawn D Parker,Prasanna Sivaprakasam,Kevin Kish,Hal Lewis,Umesh Hanumegowda,Susan Jenkins,John F Kadow,Mark Krystal,Nicholas A Meanwell,B Narasimhulu Naidu

ACS MEDICINAL CHEMISTRY LETTERS（2022）

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关键词
HIV-1 integrase, allosteric integrase inhibitors, ALLINI, lipidosis, vacuolation
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