Impact of TSPO Polymorphism on [18F]ge-180Binding in Healthy and Pseudoreference Tissue of Neurooncological and Neurodegenerative Disorders

Ziel/Aim The 18kDa translocator protein (TSPO) is an established biomarker of microglial activity and known to be overexpressed on cancer cells. TSPO-PET tracers (e.g. 11C-PBR28) are sensitive to a single nucleotid polymorphism (rs6971) resulting in low (LAB), medium (MAB) and high (HAB) affinity binders. In this study, we evaluate the impact of rs6971 on the in vivo [18F]GE-180 signal in healthy controls and in potential pseudoreference tissue for studies of neurooncological and neurodegenerative diseases.