Impact of TSPO Polymorphism on [18F]ge-180Binding in Healthy and Pseudoreference Tissue of Neurooncological and Neurodegenerative Disorders

FJ Vettermann, S Harris, J Schmitt, M Unterrainer,S Lindner,BS Rauchmann,C Palleis,VM Milenkovic,CH Wetzel,R Rupprecht,R Perneczky, GU Höglinger, J Levin,C Haass,JC Tonn,M Niyazi,P Bartenstein,NL Albert,M Brendel

Nuklearmedizin/Nuclear-Medizin（2021）

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Abstract

Ziel/Aim The 18kDa translocator protein (TSPO) is an established biomarker of microglial activity and known to be overexpressed on cancer cells. TSPO-PET tracers (e.g. 11C-PBR28) are sensitive to a single nucleotid polymorphism (rs6971) resulting in low (LAB), medium (MAB) and high (HAB) affinity binders. In this study, we evaluate the impact of rs6971 on the in vivo [18F]GE-180 signal in healthy controls and in potential pseudoreference tissue for studies of neurooncological and neurodegenerative diseases.

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