The Role of Autophagy and Vesicular Trafficking in Melanoma Development

The role of autophagy and vesicular trafficking in carcinogenesis, including melanoma, is ambiguous: on the one hand, they contribute to the maintenance of intracellular homeostasis and the tumor progression, on the other hand, they can initiate cancer cell death. These processes have a significant impact on the metabolism of melanoma cells and could be associated with metastasis, tumor growth and progression. The review examines the mechanisms of autophagy and vesicular trafficking and presents the modern literature data demonstrating the role of the intracellular transport system in oncogenesis and melanoma development. A literature search was performed in the PubMed database.