Necrotizing Myopathy Phenotype in a Patient with Active Antisynthetase Syndrome

Antisynthetase syndrome is a systemic autoimmune myopathy characterized by interstitial lung disease, myositis, arthritis, as well as fever, Raynaud's phenomenon, and "mechanic's hands".Laboratory data is characterized by the present of autoantibodies against aminoacyl transfer RNA synthetases.In clinical practice, some clinical features have been known to predominate with different intensities.Herein, we report a patient with antisynthetase syndrome with severe muscle activity that resembled immunemediated necrotizing myopathy.