Cancer-associated Adipose-Derived Mesenchymal Stem Cells Promote Migration and Invasion in Kidney Cancer

were isolated from the in (RCC-MSC) and transplantation donors (Donor-MSC) for use as controls. Several RCC cell lines were co- cultured with the A-MSCs, then analyzed for their migration and invasive ability. Molecular pathways activated in the RCC-MSCs and isolated RCC cultures were assessed. Beta-catenin in perirenal fat from surgical specimens from RCC patients was stained by immunohistochemistry (IHC). higher levels of mRNAs encoding Hes1, Hey1, and Twist, higher protein levels of beta-catenin, reduced protein levels of phospho-Akt (Ser473) phospho-p38 MAPK relative to Donor-MSCs results compared molecular pathways.