P546. Preclinical Characterization and Phase 1 Evaluation of the Tolerability, Pharmacokinetics, and Enzyme Occupancy of MK-8189, a Novel PDE10A Inhibitor

Sean Smith,Jason Uslaner,Monika Kandebo,Eric Hostetler,Izzat Raheem,Mark Layton,Liza Gantert,Kerry Riffel,Christopher Cox,Sauzanne Khalilieh,Inge De Lepeleire,Guy Bormans,Marleen Depre,Jan de Hoon,Koen Van Laere

Biological psychiatry（2022）

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PDE10A inhibitors,MK-8189,SCHIZOPHRNEIA,Cognitive Functioning

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