P307. Dysregulated Kinase Networks in Major Depressive Disorder

Major depressive disorder (MDD) is a chronic debilitating disorder with an unknown etiology. MDD is associated with the altered expression and activity of protein kinases, which regulate signaling in complex biological networks. Abnormalities in kinase signaling are involved in the pathophysiology of MDD. However, of the hundreds of kinases expressed in human brain, only a small number have been studied in MDD.