Preclinical Characterization of ASP2713, a Novel Ig and FcRIIB Cross-Linking Antibody, for Prediction of Human Pharmacokinetics and Clinically Effective Dose

Kentaro Konishi,Koji Nakamura, Yuichi Hanada,Yukihiro Kitanaga,Satoshi Kubo,Fumitaka Kinugasa,Daisuke Yamajuku,Masashi Maeda,Nobuchika Yamamoto,Tsuyoshi Minematsu,Masato Ohbuchi,Yuya Kondo,Takayuki Sumida

Journal of Pharmaceutical Sciences（2022）

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Antibody drug,Pharmacokinetics,Pharmacodynamics,Pharmacokinetic/pharmacodynamic (PK/PD),Correlation,Mechanistic modeling,Interspecies (dose) scaling,Immunotherapy,Receptor

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