Submucosal Tunneling Endoscopic Septum Division for Esophageal Diverticulum with a Median Follow-Up of 39 Months: a Multicenter Cohort Study.

Background and Aims: Submucosal tunneling endoscopic septum division (STESD) is an endoscopic minimally invasive technique for treating esophageal diverticulum. The objectives of this study were to evaluate the safety and efficacy of STESD and its impact on patients' quality of life. Methods: This study included consecutive patients who underwent STESD for esophageal diverticulum from April 2016 to August 2020 in 2 centers (Zhongshan Hospital, Fudan University and Tianjin First Central Hospital). Esophago-gram and endoscopic examination were performed before STESD and 30 days after STESD. Patients completed the 36-item Short Form survey (SF-36) before STESD and 1 year after surgery. Clinical symptoms were assessed via tele -health every 6 months until August 2021. Costamagna and Eckardt scores were used to evaluate changes in symptoms. Results: Twenty-one patients were included. Mucosal injury 1 to 2 cm below the septum occurred in 2 patients. No severe surgical adverse events were observed. Median duration of follow-up was 39 months (range, 12-63). Total SF-36 scores increased from 118.7 +/- 18.6 before STESD to 132.4 +/- 9.1 at 1 year after the procedure (P = .007). SF-36 subscales of general health (P = .002), vitality (P = .004), social functioning (P = .030), and mental health (P = .020) improved significantly after STESD. The mean Costamagna score decreased from 3.83 +/- 1.33 to 1.67 +/- 1.51 (P = .010), whereas the mean Eckardt score decreased from 3.50 +/- .90 to 1.25 +/- 1.76 (P = .002). One patient developed symptom recurrence at 10 months after STESD. Conclusions: STESD is a safe and valid endoscopic minimally invasive surgery for esophageal diverticulum, which can reduce symptoms and improve quality of life.