Nonylphenol induces anxiety-like behavior in rats by regulating BDNF/TrkB/CREB signal network
Food and Chemical Toxicology(2022)
摘要
This study aimed to verify whether chronic exposure to nonylphenol (NP) induces anxiety behavior in rats and explored NP's regulatory effect on the BDNF/TrkB/CREB signal network in vitro. Anxiety-like behavior was assessed by elevated plus-maze and light-dark box tests. The residence time in the closed arm increased with NP dose (4, 40 mg/kg) and exposure time (3 and 6 months) (P < 0.05). The hippocampal neurons in the medium dose (M-NP, 4 mg/kg) and high dose (H-NP, 40 mg/kg) groups showed disorderly arrangement, cell swelling, and nuclear pyknosis/necrosis. The protein/mRNA expressions of BDNF/TrkB/CREB in the H-NP group decreased, and the decrease was more significant at 6 months (P < 0.05). Both, NP exposure and BDNF knockdown, increase the number of apoptotic cells (P <0.001). NP downregulated the proteins/mRNA expressions of BDNF/TrkB/CREB, and the trend was consistent with the BDNF silence group. Chronic exposure to NP could induce anxiety-like behavior in rats and reduce the expression of key proteins/genes in the BDNF/TrkB/CREB signaling network.
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关键词
Nonylphenol,Anxiety,BDNF,TrkB,CREB,N2a
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