Comprehensive approach: Neurogenesis, extracellular matrix, autophagy and immune dysfunction as treatment targets in neurodegeneration as in ALS - Reorganizing physiological repair

Constant physiological remodeling and repair are increasingly dysfunctional in several essential brain systems during neurodegenerative disorders. Once chronic neuroinflammatory mechanisms are activated, a machinery of major cytokines - among them an upregulated TGF-β system - are pushing this process forward. By hitting the TGF-β system as such crucial single target, our aim was to reach many critical downstream mechanisms of neurodegeneration at one time for a long-term treatment approach.