EBOLA VIRUS DISEASE DYNAMICS WITH SOME PREVENTIVE MEASURES: A CASE STUDY OF THE 2018–2020 KIVU OUTBREAK

To fight against Ebola virus disease, several measures have been adopted. Among them, isolation, safe burial and vaccination occupy a prominent place. In this paper, we present a model which takes into account these three control strategies as well as the indirect transmission through a polluted environment. The asymptotic behavior of our model is achieved. Namely, we determine a threshold value [Formula: see text] of the control reproduction number [Formula: see text], below which the disease is eliminated in the long run. Whenever the value of [Formula: see text] ranges from [Formula: see text] and 1, we prove the existence of a backward bifurcation phenomenon, which corresponds to the case, where a locally asymptotically stable positive equilibrium co-exists with the disease-free equilibrium, which is also locally asymptotically stable. The existence of this bifurcation complicates the control of Ebola, since the requirement of [Formula: see text] below one, although necessary, is no longer sufficient for the elimination of Ebola, more efforts need to be deployed. When the value of [Formula: see text] is greater than one, we prove the existence of a unique endemic equilibrium, locally asymptotically stable. That is the disease may persist and become endemic. Numerically, we fit our model to the reported data for the 2018–2020 Kivu Ebola outbreak which occurred in Democratic Republic of Congo. Through the sensitivity analysis of the control reproduction number, we prove that the transmission rates of infected alive who are outside hospital are the most influential parameters. Numerically, we explore the usefulness of isolation, safe burial combined with vaccination and investigate the importance to combine the latter control strategies to the educational campaigns or/and case finding.