Antibacterial and Antifungal activity of Persicaria Barbata (L.) Hara (PBH) from district Bhimber (AJK), Pakistan

Plants are essential resources, as we rely on them for food, medicines, fodder, air, and many more. Plants are really important for this planet and all living things found here. The current was carried out to check the antimicrobial activity of Persicaria barbata (L.) Hara. which belongs to family Polygonaceae. Ethnobotanical survey confirmed that this plant have great medicinal potential and used to cure the number of common illness. Phytochemical profiling proved that it has rich source of different phytochemicals which are key source of diseases cure. In the analysis, four bacterial strains were used viz: Pseudomonas aeruginosa (ATCC 10145) and Escherichia coli (ATCC 10799) were Gram -ve and two positive strains: Staphylococcus aureus (ATCC 29213) and Bacillus subtilis (ATCC 11774) were used. Four fungal strains, i.e. Aspergillus oryzae (ATCC 42149) and Aspergillus niger (FGSC A1513), Fusarium oxysporum (KP297995) and F. solani (TIMM1303) were used for antimycotic analysis. In antibacterial analysis, the highest zone of inhibition (ZI) was calculated for MEOH of stem extract 33 +/- 0.5 against E. coli and AI was 0.78 followed by ZI 32 +/- 0.4 and Al was 0.88 against B. subtilis. While leaf extract depicted highest ZI 39+0.3 against S. aureus in P.E followed by methanol that is 38 +/- 0.7mm where standard values were 40 +/- 0.5 mm. For antifungal analysis, it was found that highest ZI was measured in P.E of leaf 30 +/- 0.5 against A. niger, similarly the highest value was observed in case of leaf extract in PE 40 +/- 0.7 against A. niger that is very near to standard value 52 +/- 0.5. All these finding proved that plants have good medicinal potential and can be used for treatment for many fungal and bacterial infection. All these findings also leads us to work for novel drugs discovery and development though using dedicated analytical techniques.