Investigating the Role of Chromatin Compaction at the Nano-Scale in Hutchinson-Gilford Progeria Syndrome Using Expansion Microscopy

Hutchinson-Gilford progeria syndrome (HGPS) is a genetic disease causing the early onset of age-related symptoms and leading to premature death. HGPS is associated with mutations in the LMNA gene, resulting in a truncated precursor protein of the lamin A termed progerin, which causes distinctive morphological changes in the nuclear lamina. Recent studies identified the epigenetic deregulation of lamina-associated domains (LADs) as one of the main reasons for the characteristic HGPS epigenome and the modifications in chromatin accessibility.