Bis-bibenzyls, Bibenzyls, and Terpenoids in 33 Genera of the Marchantiophyta (liverworts): Structures, Synthesis, and Bioactivity

Yoshinori Asakawa,Agnieszka Ludwiczuk,Miroslav Novakovic,Danka Bukvicki,Kenneth Yongabi Anchang

JOURNAL OF NATURAL PRODUCTS（2022）

Tokushima Bunri Univ | Med Univ Lublin | Univ Belgrade | Catholic Univ Cameroon

Cited 19|Views5

Abstract

The Marchantiophyta (liverworts) are rich sources of phenolicsubstances, especially cyclic and acyclic bis-bibenzyls, which are rare naturalproducts in the plant kingdom, together with bibenzyls and characteristicterpenoids. At present, more than 125 bis-bibenzyls have been found in liverworts.They are biosynthesized from the dimerization of lunularic acid viadihydrocoumaric acid and prelunularin. The structurally unusual cyclic and acyclicbis-bibenzyls show various biological activities such as antimicrobial, antifungal,cytotoxic, muscle relaxation, antioxidant, tubulin polymerization inhibitory, and antitrypanosomal activities, among others. The present review article deals with thedistribution and structure of bis-bibenzyls, bibenzyls, and several characteristicent-sesqui- and diterpenoids in liverworts. Furthermore, the biosynthesis and total syntheses and biological activities of bis-bibenzyls are also surveyed

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Liverworts

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